The bottles were filled by the last barrel of whisky produced by the distillery in the 20th century, eleven years ago on December 31 1999.
Each of the bottles has been numbered and packaged in a hardwood box which features a piece of the ‘millennium barrel’s’ charred stave.
Kris Comstock, Buffalo Trace brand manager, said: “This was a special barrel of whiskey and we want to do something with the bottles to help those in need.
“We really hope whiskey enthusiasts and collectors will help some deserving non-profit groups raise serious money. Our goal is to raise $200,000 for charity.”
The bottles will be distributed to charities across the US. To be considered, organisations must submit an official US non-profit tax ID number and auction the bottle within the 2011 calendar year.
Applications will be taken online at www.buffalotacemillennium.com.